Sorting out Toll Signals
نویسندگان
چکیده
منابع مشابه
Sorting out Toll Signals
Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there i...
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Speech analysis is a prototypical categorical mechanism that has been examined behaviorally in work going back to Haskins Laboratory studies in the 1950s: such work examined the perception of continua between phonemes and demonstrated sharp discontinuities consistent with categorical perception. In this issue of Neuron, Raizada and Poldrack examine analysis mechanisms for such processing by mea...
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The purpose of this paper is to explain the various notions involved and to offer a new terminology that emphasizes their differences. There are two orthogonal aspects to zero-knowledge interactive proofs. One is the notion of zero-knowledge and the other is the notion of interactive proof. Unfortunately, these two notions are often thought to be inseparable. This confusion is reminiscent of th...
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in membrane or luminal/extracellular domains of these proteins, while somatodendritic signals, like basolateral signals, are found in cytoplasmic domains. However, Establishing and maintaining the proper spatial distribu-there are also contradictions to this " analogous mem-tion of integral membrane proteins is a functional neces-brane domain " hypothesis. Previous structure–function sity of al...
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ژورنال
عنوان ژورنال: Cell
سال: 2006
ISSN: 0092-8674
DOI: 10.1016/j.cell.2006.05.014